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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 84 for knee

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  1. A Study of Comparing Functional Outcomes after Kinematic and Mechanical Alignment in Total Knee Arthroplasty

    Rochester, MN

  2. Surgical Timing and Rehabilitation (STaR) Trial for Multiple Ligament Knee Injuries (MLKIs)

    Rochester, MN

  3. A Study of Static versus Articulating Antibiotic Spacer for Periprosthetic Joint Infection in Total Knee Arthroplasty

    Rochester, MN

  4. A Study Comparing Management of Postoperative Pain after Total Knee Replacement

    Scottsdale/Phoenix, AZ

  5. Kinematics After Total Knee Arthroplasty

    Rochester, MN

  6. Tranexamic Acid in Revision Total Joint Arthroplasty

    Rochester, MN

  7. Survivorship of Attune Primary Total Knee Prosthesis

    Scottsdale/Phoenix, AZ

  8. Using Ice Around Postoperative Total Knee Incisions – Does This Make Sense?

    Jacksonville, FL

  9. Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty

    Rochester, MN

  10. Use of Autologous Bone Marrow Aspirate Concentrate in Painful Knee Osteoarthritis

    Jacksonville, FL

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