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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 421-430 of 847 for cardiovascular

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  1. Evaluation of Rate Adaptive Pacing on Chronotropic Response in Preserved Ejection Fraction HF

    Rochester, MN

  2. A Study of Oxygen Cost of Exercise in Patients with and without Heart Failure

    Rochester, MN

  3. Cardiac Vascular Reconstruction DynaCT for TAVI Procedures

    Rochester, MN

  4. Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

    Jacksonville, FL

  5. Trifecta™ GT Post Market Clinical Follow-up

    Rochester, MN

  6. A Study to Determine the Impact of Ascorbic Acid Treatment on Vasodilation in Cardiac Surgery

    Rochester, MN

  7. A Study to Evaluate Sacubitril-Valsartan for Left Ventricular Reverse Remodeling in Adults with Congenital Heart Abnormality

    Rochester, MN

  8. A Study to Evaluate Decision-support Interventions for Atrial Fibrillation (RED-AF)

    Rochester, MN

  9. A Study to Evaluate the Effectiveness and Safety of Ralinepag To Improve Treatment Outcomes in Peripheral Arterial Hypertension (PAH) Patients

    Scottsdale/Phoenix, AZ

  10. A Study to Reduce Cardiomyopathy in Breast Cancer Patients Being Treated With Trastuzumab

    Rochester, MN

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