Clinical Trials

Inclusion Criteria:

1. Hypertension, defined as a mean supine blood pressure greater than 140/90 mmHg and taking at least one (1) standard of care therapies (including a diuretic, angiotensin converting enzyme inhibitor or angiotensin receptor blocker and a calcium channel blocker)
2. MDRD estimated GFR > 30 mL/min to be calculated at the screening visit by available serum creatinine
3. Male or female African Americans
4. Between the ages of 20 and 70 years
5. Have a body mass index (BMI) within the range of 18–40 kg/m2
6. Be able to communicate effectively with the study personnel
7. Be adequately informed of the nature and risks of the study and give written informed consent prior to receiving study medication

Exclusion Criteria:

1. Known hypersensitivity or allergy to MANP or other natriuretic peptides
2. Women of child bearing age
3. Having received any investigational drug or device within 30 days prior to entry into the study; 4) A history (within the last 2 years) of alcohol abuse, illicit drug use, significant mental illness, physical dependence to any opioid, or any history of drug abuse or addiction
4. A history of difficulty with donating blood or donated blood or blood products within 45 days prior to enrollment
5. Clinically significant new illness in the 1 month before screening in the opinion of the investigator
6. History of severe allergies
7. History of coronary artery disease, cerebrovascular disease, or syncope
8. History of epilepsy or other seizure disorder
9. History of organ transplantation
10. Malignancy within 5 years
11. Clinically significant intrinsic renal disease, renal artery stenosis, or history of fibromuscular dysplasia of the renal arteries and
12. Consumption of a phosphodiesterase-5 inhibitor