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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

Study phase

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 411-420 of 847 for cardiovascular

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  1. A Study to Evaluate Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome

    Rochester, MN

  2. Dapagliflozin in Type 2 Diabetes or Pre-diabetes, and PRESERVED Ejection Fraction Heart Failure

    Rochester, MN

  3. OPTIMIZE IDE for the Treatment of ACS

    Rochester, MN

  4. Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

    Scottsdale/Phoenix, AZ

  5. A Study to Continue to Evaluate the Safety and Clinical Performance of the MOMENTUM 3 Left Ventricle Assist System

    Rochester, MN

  6. Left Ventricular Ejection Hemodynamics in Patients with Hypertrophic Cardiomyopathy and Valvular Aortic Stenosis

    Rochester, MN

  7. Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study

    Rochester, MN

  8. A Clinical Trial to Evaluate the HeartWare Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL)

    Rochester, MN

  9. Evaluation of Rate Adaptive Pacing on Chronotropic Response in Preserved Ejection Fraction HF

    Rochester, MN

  10. Prevention of Non-Surgical Bleeding by Management of HeartMate II Patients Without Antiplatelet Therapy

    Rochester, MN

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