CCaTS-CIM-CBD Precision Medicine Award
The Precision Medicine Award, from the Mayo Clinic Center for Clinical and Translational Science (CCaTS), and the Center for Individualized Medicine (CIM), offers funds to support research on precision medicine at Mayo Clinic.
The Precision Medicine Award is designed to support projects that will lead to applications for extramural funding.
The scope of projects funded by the Precision Medicine Award should support integrating genomic sequencing and personalized medicine tools with Mayo’s wealth of clinical knowledge and expertise to uncover and apply new ways to predict, diagnose and treat disease. Proposals must be aligned to either cancer or non-cancer in addition to one or more of the four strategic focus areas:
Beyond DNA: Development of diagnostic tools and therapies informed by the integration of ‘omic’ information beyond what is described in the human genome. This multi -omic approach encompasses using multiple “omes” to better understand the mechanisms of disease processes, detection, potential prevention, and more focused therapies. Projects aligned to this focus area must include two or more high-throughput omics technologies.
High Definition Therapy (HDT): Development of therapies based on and informed by the molecular basis of human health (genomics, proteomics, epigenomics, etc.). These treatments are selective and/or designed based on the unique biological characteristics of a patient’s disease or condition. Proposals should include either a design prototype, proof-of-concept, or pilot and are intended to support programs with immediate to near-term clinical impact.
Genomics in Action: Genomics in Action seeks to reduce barriers (including cost) to genomic testing by simplifying and automating tasks such as patient consenting, test ordering, result interpretation and counseling. Simplified processes enable genomic sequencing to expand into new practice areas more successfully. Proposals will need to address the scaling of genomic testing to large populations of patients and should include either a design prototype (i.e. automated interpretation, novel support tools, repurposing of existing tools, improvement in sequencing technology or scalability); proof-of-concept (i.e. screening or diagnosis); or pilot (i.e. consenting, pre/post-test counseling, test ordering).
Omics Data Platform (ODP): The ODP is an institutional resource to store all ‘omic’ data generated on Mayo patients in both clinical and research settings. The current deployment is focused on creating easy access to and query of DNA variation across an investigator’s samples and studies. Genomic data generated from successful proposals will be loaded into the ODP. Proposals describing existing genomic datasets which can be loaded into the ODP are encouraged. Additionally, projects with existing structured clinical and/or laboratory covariant data are also encouraged. Successful applications will include support for data loading, project-specific data queries, and/or project-specific ODP interface development.
The use of initial data from the Mayo Clinic TAPESTRY study, which has collected clinical grade whole exome sequencing information from 20,000+ participants and may serve in identifying rare and undiagnosed conditions, is also encouraged.
Access the Tapestry - ICD-9/10-CM Codes and Phenotypes Browser (must be logged in to the Mayo Clinic network).
Projects must incorporate the use of CIM Programs and Services (must be logged in to the Mayo Clinic network).
Associate consultants, senior associate consultants and consultants from across Mayo Clinic are eligible for the Precision Medicine Award. Individuals in the process of transitioning from mentored career development awards to independent awards are encouraged to apply.
CCaTS and CIM anticipate funding up to two awards from this request for applications. Awards provide up to $50,000 a year (direct costs plus indirects) for one year. Extensions are considered only under extenuating circumstances.
Unallowable expenses include capital equipment and computers or laptops.
Recipients of grants or awards supported by CCaTS may be asked to review applications for other CCaTS grants.
Pre-applications (previously called letters of intent) are due by 5:00 p.m. Central time on August 13, 2021. They should be submitted through the START Application Tool (must be logged in to the Mayo Clinic network).
Pre-applications must include the CIM checklist (Word document).
Applicants are invited to submit full applications after review of the pre-applications.
Applications are due by 5:00 p.m. Central time on October 15, 2021. They should be submitted through the START Application Tool (must be logged in to the Mayo Clinic network).
The anticipated award date is December 1, 2021.
Full application requirements
Applicants are required to include the following as attachments with their full applications:
A formal Mayo Integrated Research Information System (MIRIS) budget prepared by the Office of Sponsored Projects Administration (OSPA) is not required at the time of application. If the project is selected for funding, the awardee will work with Susan (Sue) J. Rubow and OSPA to create a MIRIS funding proposal and budget.
CCaTS and CIM apply the following criteria when reviewing applications for the Precision Medicine Award:
- Scientific merit, with a strong emphasis on impact and innovation
- Likelihood of future extramural funding
- Feasibility within the time and budget proposed
- Qualifications of the investigators
Note: Access to genomic data collected as part of the Tapestry study will require IRB approval of the study aims and proposal.
Annual progress reports are required for up to two years beyond the end date of the award.
The NIH Public Access Policy requires that all publications resulting from NIH funding be uploaded to PubMed Central. Recipients of CCaTS awards, including intramurally funded awards, must follow this policy. The Mayo Clinic Public Access Policy intranet site (must be logged in to the Mayo Clinic network) guides awardees through the process of uploading publications.
Please remember to cite the Mayo Clinic CCaTS in your publication.
For scientific questions, email Robert J. Pignolo, M.D., Ph.D., Konstantinos N. Lazaridis, M.D.
For scientific questions about Tapestry study, email Teresa Kruisselbrink M.S., C.G.C., Konstantinos N. Lazaridis, M.D.
For questions about the request for applications or the START Application Tool, email Susan (Sue) J. Rubow.