Focus Areas

Areas of research currently being explored in the Department of Molecular Pharmacology and Experimental Therapeutics at Mayo Clinic include:

  • Pharmacogenomics (molecular basis of individual variation in response to drugs)
  • Cause and effects of DNA instability in human disease
  • Supercomputer-based approaches to rational drug design
  • Interaction of drugs and hormones with the genome, biology and toxicology of the cholinergic synapse
  • Cell signaling in G protein-coupled and tyrosine kinase receptor systems
  • Mechanisms of novel targeted cancer chemotherapeutics
  • Molecular biology of alcohol metabolism
  • Antidepressant drug action and resistance
  • Cellular and molecular biology of cardioprotection
  • Role of epigenetic changes in degenerative diseases and cancer
  • Systems pharmacology


Research groups and laboratories associated with the department include: