Overview

3D illustration of cryogenic electron microscopy structures of G protein-coupled receptors Recently solved cryo-EM structures

The composite image above shows cryogenic electron microscopy (cryo-EM) structures of receptors that are the focus of work in the Miller lab. From left to right: CCK1R-Gq, side view; CCK1R-Gq, top view; SecR-Gs, side view; Sec-Gs, top view

The laboratory of Laurence J. Miller, M.D., at Mayo Clinic studies the molecular pharmacology of G protein-coupled receptors. The lab has portfolios of projects directed toward the class A cholecystokinin receptor and the class B secretin receptor.

Dr. Miller's laboratory is experienced in all types of pharmacological, biochemical, cell biological and biophysical approaches to the characterization of structure, function and regulation of G protein-coupled receptors. The major impact of this research is on receptor-active drug development.

Affiliations

Dr. Miller's Molecular Pharmacology of G Protein-Coupled Receptors Lab is affiliated with: