Overview

3D illustration of cryogenic electron microscopy structures of G protein-coupled receptors. Recently solved cryogenic electron microscopy structures

The composite image above shows cryogenic electron microscopy structures of receptors that are the focus of work in the Miller lab. From left to right are CCK1R-Gq, side view; CCK1R-Gq, top view; SecR-Gs, side view; and Sec-Gs, top view.

The Molecular Pharmacology of G Protein-Coupled Receptors Laboratory led by Laurence J. Miller, M.D., studies the molecular pharmacology and drug discovery at G protein-coupled receptors. The lab has portfolios of projects directed toward the class A cholecystokinin receptor and the class B secretin receptor.

Dr. Miller's lab is experienced in all types of pharmacological, biochemical, cell biological and biophysical approaches to the characterization of structure, function and regulation of G protein-coupled receptors. The major impact of this research is on receptor-active drug development.

Affiliations

Dr. Miller's Molecular Pharmacology of G Protein-Coupled Receptors Lab is affiliated with: