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A 3-D electron microscopy reconstruction of mitochondria in the hippocampus of a mouse model of Alzheimer's disease. The mitochondria acquired a novel morphological phenotype, mitochondria-on-a-string (MOAS), which allows cells to protect mitochondrial functions under stress conditions, such as during disease or aging. Transmission electron microscopy images from approximately 28 serial sections of 0.09 μm thickness were stacked, aligned and reconstructed using 3-D reconstruction software in APP-PS1 mice at 40 weeks of age.
The Mitochondrial Neurobiology and Therapeutics Laboratory of Eugenia Trushina, Ph.D., at Mayo Clinic studies the mitochondria-based molecular mechanisms of neurological conditions.
The lab studies mitochondrial dynamics in health and disease and develops biomarker panels, tools to visualize mitochondria and mitochondria-targeted therapeutics.
Keep up to date on mitochondrial neurobiology and therapeutics research at Mayo Clinic with published articles from Dr. Trushina's laboratory.
Contact the Mitochondrial Neurobiology and Therapeutics Laboratory of Eugenia Trushina, Ph.D., at Mayo Clinic with inquiries about research or collaborations.
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