Mitochondria in the hippocampus of a mouse model of Alzheimer's disease
A 3-D electron microscopy reconstruction of mitochondria in the hippocampus of a mouse model of Alzheimer's disease. The mitochondria acquired a novel morphological phenotype, mitochondria-on-a-string (MOAS), which allows cells to protect mitochondrial functions under stress conditions, such as during disease or aging. Transmission electron microscopy images from approximately 28 serial sections of 0.09 μm thickness were stacked, aligned and reconstructed using 3-D reconstruction software in APP-PS1 mice at 40 weeks of age.