Tumors require complex interactions with surrounding blood vessels, immune cells, supportive tissue structures and cell types that are distinct to the tumor site in order to grow, become invasive and metastasize. Tumors influence their microenvironment by releasing soluble signals that lead to degradation and remodeling of the tissue structures that constrain their growth. Targeting the interactions of tumors with the microenvironment is an important and developing area of study.
The investigators in our department who focus on tumor microenvironment research are:
- Hugo Guerrero Cazares, M.D., Ph.D.: Neurogenesis and Brain Tumors Laboratory
- Baoan Ji, M.D., Ph.D.
- Keith L. Knutson, Ph.D.
- Joseph C. Loftus, Ph.D.
- Debabrata (Dev) Mukhopadhyay, Ph.D.: Tumor Angiogenesis and Vascular Biology Laboratory
- Nicole R. Murray, Ph.D.: Cell and Molecular Biology of Carcinogenesis Laboratory
- Tushar C. Patel, M.B., Ch.B.: Molecular Hepatology Laboratory
- Aneel Paulus, M.D., M.S.
- Derek C. Radisky, Ph.D.: Tumor Microenvironment Laboratory
- Evette S. Radisky, Ph.D.: Proteases in Cancer Laboratory
- Mark E. Sherman, M.D.
- Peter Storz, Ph.D.: Tumor Development, Immunology and Progression Laboratory
- E. Aubrey Thompson, Ph.D.: Hormones and Cancer Laboratory
- Nhan L. Tran, Ph.D.
- Han W. Tun, M.D.