Tumor Invasion and Metastasis
A fundamental property of malignant tumor cells is the ability to invade surrounding tissues and to metastasize to other organs. These abilities underlie the majority of cancer-associated deaths. While invasion and metastasis are often thought of as the final stages of tumor development, recent studies have shown that tumor spread can occur even at early stages of tumor development, sometimes even before the primary tumor has been identified. Development of therapies targeting invasion and metastasis has the promise to significantly reduce cancer mortality.
The investigators in our department who focus on tumor invasion and metastasis research are:
- Panagiotis Z. Anastasiadis, Ph.D.: Cell Adhesion and Metastasis Laboratory
- Hugo Guerrero Cazares, M.D., Ph.D.
- Rajappa S. Kenchappa, Ph.D.
- Joseph C. Loftus, Ph.D.
- Debabrata (Dev) Mukhopadhyay, Ph.D.: Tumor Angiogenesis and Vascular Biology Laboratory
- Alfredo Quinones-Hinojosa, M.D.: Brain Tumor Stem Cell Research Laboratory
- Evette S. Radisky, Ph.D.: Proteases in Cancer Laboratory
- Steven S. Rosenfeld, M.D., Ph.D.
- Rachel Sarabia Estrada, D.V.M., Ph.D.
- Nhan L. Tran, Ph.D.