The research of Nhan L. Tran, Ph.D., is focused on elucidating the cellular and biochemical mechanisms of action of candidate genes expressed in highly invasive cancer cells. Dr. Tran's lab is currently investigating several targets mediating cancer invasion and survival.
- Cancer genomics
- Cancer invasion and metastasis
- Genetics of invasive glioblastoma multiforme (GBM) cells
- Central nervous system metastasis
- Rho GTPase signaling
- Tumor necrosis factor receptor superfamily biology in cancer
- Identification of novel drug targets, high-throughput screening for drug discovery and development
- Intratumor heterogeneity and therapeutic resistance in GBM
Significance to patient care
Dr. Tran's research targeting tumor heterogeneity and invasive cells will prevent tumor recurrence and therapeutic resistance, resulting in improved treatments and outcomes for patients with cancer.