Jacksonville, Florida


Trifiletti.Daniel@mayo.edu Clinical Profile


As an international leader in radiation oncology and stereotactic radiosurgery, the research of Daniel M. Trifiletti, M.D., includes numerous clinical studies involving radiation, surgery and drug therapies in the treatment of tumors.

Dr. Trifiletti's short-term research goals focus on describing the impact of radiation on the priming of the brain tumor microenvironment. Discovering the biological underpinnings of radiation priming will allow for novel, "game-changing" cancer therapies, rapid translation to early-stage clinical trials and, ultimately, improved outcomes in patients with fatal diseases.

Focus areas

  • Defining the role of radiation in priming the tumor microenvironment
  • Describing the synergy between radiation and novel cellular therapies
  • Validating the use of immunomodulating agents and radiation in brain cancer
  • Identifying novel indications for intracranial functional radiosurgery

Significance to patient care

Through the focus areas above, Dr. Trifiletti's research efforts aim to rapidly impact practical outcomes. This includes lengthening life by creating therapies that kill more cancer, reducing toxicity by developing techniques to reduce the impact on normal cells, and lowering health care costs through multidisciplinary collaboration, workflow efficiency and patient safety. While primarily aimed at improving the patient care of those with brain tumors, these principles will be expanded to patients with all types of cancer.

Professional highlights

  • Editorial board member, Journal of Neuro-Oncology, 2018-present
  • Member, Science Council and Education Council, ASTRO, 2017-present
  • Recipient, Roentgen Resident/Fellow Research Award, Radiological Society of North America, 2015, 2017, 2018


Primary Appointment

  1. Consultant, Department of Radiation Oncology

Joint Appointment

  1. Consultant, Department of Neurosurgery
  2. Consultant, Department of Cancer Biology

Academic Rank

  1. Professor of Radiation Oncology


  1. Chief Resident - Radiation Oncology University of Virginia
  2. Visiting Resident - Adult Proton Beam Therapy University of Florida
  3. Visiting Resident - Pediatric Proton Beam Therapy University of Pennsylvania
  4. Residency - Radiation Oncology University of Virginia
  5. Graduate Certificate - Clinical Research University of Virginia
  6. Graduate Certificate - Health Systems and Policy University of Virginia
  7. Internship - Medicine University of Florida
  8. MD - Medicine with Honors in Research University of Florida
  9. BS with Distinction - Mathematics & Cognitive Neuroscience University of Florida

Clinical Studies

Learn about clinical trials that address specific scientific questions about human health and disease.

See my studies.

Explore all research studies at Mayo Clinic.


See the peer-reviewed findings I have published as a result of my research.

Review publications.

Mayo Clinic Footer