The Mayo Clinic Neurogenesis and Brain Tumors Laboratory, under the direction of Hugo Guerrero Cazares, M.D., Ph.D., focuses on understanding the interaction of the human neurogenic niche and brain tumors. Specifically, Dr. Guerrero Cazares' research team conducts in vitro, in vivo and ex vivo studies on glioblastoma multiforme — the most common, aggressive and proliferative primary brain tumor in adults — and on the migration of neural progenitor cells in people.

Areas of interest

Specific areas of interest in the Neurogenesis and Brain Tumors Laboratory include:

  • Understanding the role of cerebrospinal fluid on the invasiveness of brain tumor cells
  • Studying the potential malignant transformation of human neural progenitor cells in proximity with brain tumors
  • Studying the invasion of healthy brain by tumor cells ex vivo

Neurogenesis and Brain Tumors Laboratory


Dr. Guerrero Cazares' lab is affiliated with several Mayo Clinic research areas and programs:

About Dr. Guerrero Cazares

Hugo Guerrero Cazares, M.D., Ph.D., is an associate professor of neurosurgery at Mayo Clinic College of Medicine and Science in Jacksonville, Florida. Dr. Guerrero Cazares' research is focused on the study of brain tumor cell migration and the interaction of brain tumor cells with neural progenitor cells.

Dr. Guerrero Cazares obtained his medical and doctoral degrees from the University of Guadalajara in Mexico. He then continued his training as a fellow in the department of neurosurgery at Johns Hopkins University in Baltimore.