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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 131-140 of 2188 for surgery

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  1. High-dose Hydroxocobalamin (Vitamin B12a) for Vasopressor Refractory Hypotension Following Cardiopulmonary Bypass

    Rochester, MN

  2. Reverse Total Shoulder Arthroplasty versus Nonoperative Treatment of 3 & 4-Part Proximal Humerus Fractures

    Rochester, MN

  3. A Study to Evaluate NextScience® Xperience™ versus Normal Saline Irrigation Solution for Decreasing Bioburden After Primary Total Hip and Knee Arthroplasty

    Jacksonville, FL

  4. A Study to Analyze Surgical Outcomes and Predictors of Treatment for Hip Diseases

    Rochester, MN

  5. Ultrasonic Energy for Pulmonary Artery Branch Sealing During VATS Lobectomy

  6. Pericardial Resection to Treat Heart Failure

    Rochester, MN

  7. A Study to Test the Safety and Effectiveness of the Spatz3 Adjustable Balloon System to Help Obese People Lose Weight

    Rochester, MN

  8. Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

    Albert Lea, MN, Jacksonville, FL, La Crosse, WI, Mankato, MN, Rochester, MN

  9. Patient-Centered Outcomes in the Surgical Treatment of Uterovaginal Prolapse

    Jacksonville, FL

  10. Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

    Rochester, MN

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