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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 131-140 of 2195 for surgery

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  1. Reverse Total Shoulder Arthroplasty versus Nonoperative Treatment of 3 & 4-Part Proximal Humerus Fractures

    Rochester, MN

  2. Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients with Early-Stage Breast Cancer that was Removed by Surgery

    Eau Claire, WI

  3. Patient-Centered Outcomes in the Surgical Treatment of Uterovaginal Prolapse

    Jacksonville, FL

  4. Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

    Albert Lea, MN, Jacksonville, FL, La Crosse, WI, Mankato, MN, Rochester, MN

  5. Pericardial Resection to Treat Heart Failure

    Rochester, MN

  6. Head-up Display for Ultrasound Guided Procedures and Image-Guided Surgical Procedures

    Jacksonville, FL

  7. A Study to Evaluate Post-surgical Outcomes Using the Early Recovery After Surgery (ERAS) Protocol for Posterior Cervical Decompression and Fusion

  8. Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

    Rochester, MN

  9. Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty

    Scottsdale/Phoenix, AZ

  10. High-dose Hydroxocobalamin (Vitamin B12a) for Vasopressor Refractory Hypotension Following Cardiopulmonary Bypass

    Rochester, MN

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