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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 121-130 of 2188 for surgery

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  1. Robotic vs. Open NSM for Early Stage Breast Cancer

    Jacksonville, FL, Rochester, MN

  2. Carboplatin and Paclitaxel With or Without Atezolizumab Before Surgery in Treating Patients With Newly Diagnosed, Stage II-III Triple-Negative Breast Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL

  3. Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival

    Rochester, MN, Jacksonville, FL

  4. Abdominal Ice Packs for Pain Control and Reduction of Narcotic Use Following Laparoscopic Hysterectomy

    Rochester, MN

  5. Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

  6. A Study of Computer Simulation of Endovascular Repair of Cerebral Aneurysms Aneurysms

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  7. Head-up Display for Ultrasound Guided Procedures and Image-Guided Surgical Procedures

    Jacksonville, FL

  8. Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients with Early-Stage Breast Cancer that was Removed by Surgery

    Rochester, MN, Scottsdale/Phoenix, AZ

  9. Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients with Early-Stage Breast Cancer that was Removed by Surgery

    Eau Claire, WI

  10. A Study of Minimally Invasive Pericardiotomy as a New Treatment for Heart Failure

    Rochester, MN

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