A Study of Giving Celecoxib and Dexamethasone with Manipulation Under Anesthesia to Treat Postoperative Stiffness after Total Knee Replacement Surgery


About this study

The purpose of this study is to compare the outcome following manipulation under anesthesia for stiffness with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Measured outcomes will include pain, range of motion, as well as subjective outcome scores.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Subjects who have received a primary unilateral total knee arthroplasty for a diagnosis of osteoarthritis.
  • Manipulation under anesthesia scheduled 4-12 weeks postoperatively.
  • Subjects if they are on any NSAIDs prior to MUA.

Exclusion Criteria

  • Intolerance to NSAIDs.
  • Renal dysfunction.
  • Age < 18 or > 90 years.
  • Primary diagnosis of rheumatoid arthritis.
  • Patients with a Glomerular Filtration Rate (GFR) <60 as the cut off for Chronic Kidney Disease (CKD) (stage 3 CKD).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Matthew Abdel, M.D.

Closed for enrollment

Contact information:

Lauren Cole B.S.

(507) 266-1227


More information


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