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The Brain Tumor Patient-Derived Xenograft National Resource characterizes and provides phenotypic and molecular information about patient-derived xenograft cell lines, allowing researchers to readily identify tumor lines of greatest interest for their research on brain cancer and glioblastoma. Services also include genome-wide profiling data, tumor extracts, frozen PDX tumor tissue, cryopreserved PDX tissue and derivative PDX cell lines.
The PDX National Resource at Mayo Clinic operates under the direction of Jann N. Sarkaria, M.D., and his Translational Neuro-Oncology Lab.
The PDX National Resource at Mayo Clinic provides a highly annotated series of brain tumor PDX models with levels of multi-omic characterizations comparable to those provided for patient tumors by The Cancer Genome Atlas.
Growth characteristics, invasiveness, molecular subtypes, tissue microarray data and de-identified clinical information are available for PDX models in the PDX National Resource.
Platforms and methodology information for genomic alterations, cBioPortal, RNAseq method, WES method and methylation array method in the PDX National Resource.
DNA submitted for whole-exome sequencing was analyzed by short-tandem repeat to ensure that the DNA submitted was for the correct PDX line. An authentication of resources letter is also available for the NIH.
Information is available about the techniques and methodology for establishing PDX lines, serial passaging, in vitro culture, tumor implantation and cryopreservation.
Lysates, DNA, cDNA, frozen tumor, cryopreserved tumor and other PDX samples are available through the PDX National Resource. A collaboration letter also can be provided.
The Mayo Clinic Brain Tumor PDX models have been widely distributed in the neuro-oncology research community and used in more than 100 peer-reviewed manuscripts.
Contact Dr. Sarkaria or his team in the PDX National Resource to request PDX samples or to get more information about services, techniques and materials transfer agreements.
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