Mayo GBM PDX Line Data
To help researchers plan for experiments and studies, the Mayo Clinic Brain Tumor PDX National Resource offers information about growth characteristics, invasiveness and subtypes for patient-derived xenografts (PDXs), along with tissue microarray data and de-identified clinical data from patient electronic records.
We've also cataloged, analyzed and performed sequencing on tumor samples.
Detailed information about the model and characteristics can be found in the article "Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma," published online in Clinical Cancer Research by Mayo Clinic pathologist Rachael A. Vaubel, M.D., Ph.D., on Dec. 18, 2019.
Explore these categories in the database:
- Phenotype: growth characteristics of each PDX
- Cell culture information: PDX cell line proliferation and passaging information
- Genotype: common genomic alterations commonly found in glioblastoma, including MGMT methylation and IDH status
- Copy number variation (CNV)
- Invasiveness: determined by immunofluorescent (IF) staining
- Clinical information: de-identified from medical records
- Available samples: cells, tissues and extracts
- TMA (PDX tissue microarray): map and results
- -Omic platforms: available for each line
- STR data: short tandem repeat line authentication