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Dr. Dickson is involved with various research collaborations at Mayo Clinic and other institutions.
Dr. Bieniek received his Ph.D. from Mayo Graduate School in 2016 under the mentorship of Dr. Dickson. Currently Dr. Bieniek is an assistant professor in the Department of Pathology and director of the Glenn Biggs Institute brain bank at the University of Texas Health Science Center at San Antonio. As a research collaborator at Mayo Clinic, Drs. Bieniek and Dickson, together with colleagues at Boston University and Mount Sinai Hospital, are aiming to understand the pathophysiology of repetitive traumatic brain injuries by studying the neurodegenerative disorder chronic traumatic encephalopathy (CTE) and other age-associated tau pathologies.
A clinician-scientist specializing in geriatric psychiatry and dementia syndrome, Dr. Kasanuki received his Ph.D. in psychiatry and behavioral science with a concentration in neuropathology from Juntendo University, Tokyo, in 2012. For a decade, his research has been focused on both clinicopathological and clinical studies in dementia with Lewy bodies (DLB). Dr. Kasanuki joined Dr. Dickson's lab from 2015 to 2017 as a visiting scientist and research fellow. Most recently, Dr. Kasanuki has been working on a clinical study in memory that aims to develop a brief questionnaire for detection of prodromal Lewy body disease. In addition to this research work, he has been a member of the DLB support network (DLBSN) in Japan, founded by psychiatrist Kenji Kosaka, M.D., supporting people with DLB, their families and caregivers, as an expert advisory doctor.
Frontal Cortex = Pathological Aging versus Alzheimers
Argyrophilic grain disease as seen under the microscope: Tau positive grains and "pre-tangles" in limbic gray; dentate lesions; coiled bodies in white matter; ballooned neurons in limbic lobe in some cases.
Frontotemporal dementia and TDP (microscopic findings): Cortical superficial spongiosis; gliosis in gray and white matter; no Alzheimer plaques or tangles; caudate atrophy and spongiosis is common.
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