Rochester, Minnesota Clinical Profile


The research of Keith A. Josephs, M.D., focuses on the relationship between clinical diagnoses, neuroimaging and the neuropathological underpinnings accounting for neurodegenerative diseases. Neurodegenerative diseases of particular interest include progressive supranuclear palsy, corticobasal degeneration, apraxia of speech, semantic dementia, primary progressive aphasia and posterior cortical atrophy.

Dr. Josephs is currently the principal investigator of multiple National Institutes of Health grants and foundation grants and co-investigator of multiple foundation grants.

Focus areas

  • Progressive apraxia of speech
  • Progressive supranuclear palsy
  • Alzheimer's disease
  • Frontotemporal dementia
  • Semantic dementia

Significance to patient care

Dr. Josephs' research aims to identify new ways to diagnosis and treat patients with devastating neurodegenerative diseases. Dr. Josephs and his team recently identified a new link between a protein known as TDP-43 and Alzheimer's disease. This breakthrough will lead to new approaches aimed at the treatment of Alzheimer's disease. Coverage of Dr. Josephs' work has been featured in major media outlets such as Bloomberg News and the Minneapolis StarTribune.

Professional highlights

  • Editorial board, Parkinsonism & Related Disorders journal (beginning 2015); Neuropathology and Applied Neurobiology journal (2014-present); Neuroscience Discovery journal (2013-present); Acta Neuropathologica journal (2001-present)
  • Ani Professor of Alzheimer's Disease Research, 2021
  • Norman Geschwind Prize in Behavioral Neurology, American Academy of Neurology (AAN), 2010
  • Judson Daland Prize for Outstanding Achievement in Clinical Investigation, American Philosophical Society, 2009
  • Harold Brenner Pepinsky Early Career Award in Neurobehavioral Science, Ohio State University Medical Center, 2009
  • Research Award in Geriatric Neurology, AAN, 2008


Primary Appointment

  1. Consultant, Department of Neurology

Academic Rank

  1. Professor of Neurology
  2. Professor of Neuroscience


  1. MSc - Clinical and Translational Research Mayo Clinic in Rochester
  2. Fellow - Dementia & Degenerative Neuropathology National Hospital for Neurology and Neurosurgery
  3. Fellow - Movement Disorders Mayo Clinic in Rochester
  4. Resident - Neurology Mayo Clinic in Rochester
  5. Transitional Year Mayo Clinic in Florida
  6. MD Medical College of Pennsylvania
  7. MST - Majors: Education; Abstract Mathematics. Minor: Chemistry University of Florida
  8. BS - Pure Mathematics University of Florida
  9. AA Miami-Dade Community College

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