Type 1 Diabetes Mellitus

High PRS

A high PRS is associated with 12 to 20 times increased risk for developing Type 1 Diabetes Mellitus (DM) relative to a person not in the high-risk category. The data is based on populations of African and European descent. Information is insufficient or not available for populations of other descent. For participants with a high PRS, recommendations include:

• Counsel the individual and their family about early symptoms of Type 1 DM and when to alert their medical provider.
• Consider yearly autoantibody testing up to age 17.
• If screening is abnormal (2 or more positive antibodies) or symptoms of Type 1 DM are present, referral to endocrinology.
• Additional screening may be considered by an endocrinologist or PCP. This may include HbA1C, regular fasting glucose screening, or at-home urinalysis for glucose and ketones (approximately every 3 months).