Factors Assessed

The Genome Informed Risk Assessment (GIRA) report summarizes risk factors for common diseases. It assesses nine conditions for adult participants (18 years or older) and four conditions for children. Participants are identified as high-risk based on specific criteria for each condition. The GIRA report is provided to both clinicians and participants, and its impact assessed in the form of clinical actions taken by clinicians and patients to mitigate disease risk.

The GIRA report includes an assessment of the following factors to estimate a participant's risk of developing a disease:

The Genome Informed Risk Assessment combines clinical factors, family history, polygenic determinants, monogenic determinants and social determinants.