Conditions Assessed

Clinical recommendations included in the GIRA report are based on current guidelines and expert opinion. The recommendations take into account a participant's genetic risk, family history, and clinical risk for each condition.

For well-studied conditions that have proven preventive measures, polygenic risk scores (PRSs) may guide medical care and/or lifestyle changes that can be implemented to mitigate overall disease risk. However, currently there are no standard guidelines for using PRSs in medical management.

Condition-specific recommendations:

The eMERGE Study tests for bronchial asthma, atrial fibrillation, breast cancer, chronic kidney disease, colorectal cancer (monogenic only), coronary heart disease, hypercholesterolemia, obesity, prostate cancer, and diabetes mellitus types 1 and 2.