The Department of Biochemistry and Molecular Biology at Mayo Clinic makes significant contributions to the Mayo Clinic mission through nationally and internationally recognized biomedical research and the training of students, fellows and clinicians.

The Department of Biochemistry and Molecular Biology is Mayo's largest basic science department, composed of more than 55 faculty members. The faculty includes both primary members and joint appointees whose primary appointments are in a variety of other departments and divisions, including cardiovascular diseases, pediatric and adolescent medicine, pulmonary and critical care medicine, gastroenterology and hepatology, molecular medicine, nephrology and hypertension, clinical genetics and genomics, and orthopedic surgery.

This talented and diverse faculty participates in graduate education through Mayo Clinic Graduate School of Biomedical Sciences, loosely organized into three educational subtracks: biochemistry and structural biology, cell biology and genetics, and cancer biology. Department members contribute significantly to the core didactic graduate-level education of all Mayo Clinic Graduate School of Biomedical Sciences doctoral students in molecular cell biology, genome biology, genetics, biochemistry, mechanisms of disease and a series of advanced graduate tutorials that provides an important extension to the core curriculum.

Besides undertaking fundamental studies into the molecular mechanisms of life, many faculty members study the molecular basis of disease conditions such as cancer, heart disease, diseases of the nervous system and genetic disorders. Many of the department's laboratories use model systems such as rodents, zebrafish, Drosophila, Caenorhabditis elegans, yeast and bacteria to approach and dissect complicated biological questions.

In addition to conducting outstanding research, faculty members direct and maintain many of the Mayo Clinic institutional core facilities, providing state-of-the-art technology for all scientists and clinicians at Mayo Clinic in the areas of electron microscopy, nuclear magnetic resonance spectroscopy and imaging, proteomics and mass spectroscopy, genomics and molecular biology, and knockout mouse technology. These facilities form an essential part of the Mayo Clinic research base.