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A Study to Determine the Effectiveness of Spinal Cord Stimulation for the Treatment of Refractory Angina Pectoris
Rochester, MN
The purpose of this study is to perform an in-depth review of pre-operative considerations and indications for spinal cord stimulation (SCS) for refractory angina pectoris (RAP), intraoperative findings, and postoperative reports of any adverse events and (secondarily) patient reports of effectiveness with this therapy.
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A Study Of Spinal Stimulation After Spinal Cord Injury
Rochester, MN
The purpose of this study is to determine responsiveness (present or absent) of spinal sensorimotor circuitry below the level of SCI via transcutaneous spinal cord stimulation (TSCS)-evoked motor evoked potentials (MEPs) in individuals with SCI below T10.
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A Study to Evaluate Patient Experience Comparing Tonic vs. Burst Spinal Card Stimulation for Chronic Pain
Jacksonville, FL
The purpose of this study is to evaluate if subjects who have already experienced tonic spinal cord stimulation would have a better pain relief status with burst spinal cord stimulation
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Service Line TransPerc
Rochester, MN
The purpose of this study is to compare transcutaneous electrical spinal stimulation and epidural electrical spinal stimulation. Relationships between stimulation input and electrophysiological output will be recorded, and changes in motor, sensory, and functional outcomes during and after stimulation will be assessed.
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Acute And Chronic Repercussion Of Spinal Cord Stimulation After Spinal Cord Injury
Rochester, MN
The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune & cardiovascular function in participants with spinal cord injury.
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A Study Of Spinal Cord Stimulation For Treatment Of Chronic Regional Pain
Rochester, MN
The purpose of this study is to identify SCS parameters that affect neurophysiology related to leg pain.
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A Study to Compare HF10 Therapy Combined with Conventional Medical Management (CMM) to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain
Rochester, MN
The purpose of this study is to document the safety, clinical effectiveness and cost-effectiveness of high-frequency HF10™ Therapy, delivered through the Senza system, in subjects with chronic refractory back pain (with or without leg pain) who are not considered candidates for spine surgery. This study is a multi-center, prospective, randomized study to compare the two treatment groups.
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Dorsal spinal cord stimulation vs medical management for the treatment of low back pain
Rochester, MN
The purpose of this study is to evaluate the effectiveness of BurstDRTM spinal cord stimulation, compared with comprehensive medical management, in improving pain and back-related physical function in patients suffering with chronic, refractory axial low back pain with a neuropathic component, who have not had lumbar spine surgery and for whom surgery is not an option.
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Study to Assess Painful Diabetic Peripheral Neuropathy After High-frequency Spinal Cord Stimulation
Rochester, MN
The purpose of this study is to assess painful diabetic peripheral neuropathy after high-frequency spinal cord stimulation.
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A Study to Evaluate Neurostimulation to Treat Chronic Upper Limb Pain After Brachial Plexus Injury
Rochester, MN; Jacksonville, FL
This study is designed to assess the degree to which high-frequency spinal cord stimulation may help with pain after brachial plexus avulsion injury.
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Spinal Cord Stimulation to Treat Chemotherapy-Induced Peripheral Neuropathy
Rochester, MN
The purpose of this study is to understand pain outcomes in patients with cancer who have Chemotherapy-Induced Peripheral Neuropathy (CIPN).
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A Study to Compare HF10 Therapy Combined With CMM to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain
Scottsdale/Phoenix, AZ
The purpose of this study is to document the safety, clinical effectiveness and cost-effectiveness of high-frequency SCS at 10 kHz (HF10™ Therapy) delivered through the Senza system in subjects with chronic refractory back pain (with or without leg pain) who are not considered candidates for spine surgery. This study is a multi-center, prospective, randomized study to compare the two treatment groups.
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A Study to Determine the Long-Term Real-World Outcomes on Patients Implanted With a Neurostimulator
Rochester, MN
The study is being conducted to gain a broader understanding of how Abbott’s neurostimulation systems are being used in the real-world setting. It will serve the dual purpose of collecting long-term safety and effectiveness of these devices and obtaining information about the different patient populations who are using them.
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A Study to Survey Epidural User Experience for Individuals with Spinal Cord Injury Paralysis
Rochester, MN
This is a survey study to identify user-reported motor, sensory, and autonomic functions that are enabled by epidural stimulation, establish correlations between epidural stimulation usage, rehabilitation, functional gains, and user experience in the laboratory and community settings, and to understand and identify subjective goals, benefits, and barriers that still exist with implanted epidural stimulator community.
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A Study Using Spinal Stimulation During Exercise in Patients with Heart Failure
Rochester, MN
The purpose of this study is to determine if epidural spinal cord stimulation can affect blood pressure control and blood vessel resistance during exercise in heart failure patients by intercepting messages of muscle fatigue and shortness of breath.
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A Study of Transcutaneous and Epidural Spinal Stimulation for Enabling Motor Function in Humans with Motor Complete Paraplegia
Rochester, MN
The purpose of this study is to characterize and compare sensorimotor activity in muscles below the level of injury during Transcutaneous Epidural Spinal Stimulation (TESS) and Epidural Electrical Stimulation (EES)-enabled motor tasks, and to assess and compare changes in clinical outcomes over the course of rehabilitation with TESS and EES.
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Spinal Cord Injury Epidural Stimulation
Rochester, MN
This is a feasibility study to test the use of epidural stimulation to restore volitional function previously lost due to spinal cord injury. Previous studies conducted in animal models, performed elsewhere and here at Mayo Clinic, have shown that direct electrical stimulation of the spinal cord increases the excitability of spared neuronal connections within the site of injury, thereby enhancing signal transmission and allowing recovery of previously lost volitional function. Recently, epidural electrical stimulation of the lumbosacral spinal cord in four individuals with spinal cord injury (SCI) has restored motor and autonomic function below the level of injury. Despite positive ...
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Epidural and Dorsal Root Stimulation in Humans with Spinal Cord Injury
Rochester, MN
A study to compare electrophysiologic activity of epidural stimulation and dorsal root ganglion stimulation, as well as quantify changes in motor performance with both types of stimulation over the course of 10 rehabilitation sessions.
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Analysis of Spinal Cord Stimulation Usage Over a 15-Year Period
Scottsdale/Phoenix, AZ; Rochester, MN
The purpose of this study is to determine the rate at which patients who underwent Spinal Cord Stimulation (SCS) trial ultimately progressed to SCS implantation, determine the percentage of patients who continued using their SCS system after 5 years, as well as identify patient characteristics that lead to SCS discontinuation.
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A Study to Evaluate Mobility and Therapeutic Benefits Resulting from Exoskeleton Use in a Clinical Setting
Rochester, MN
The proposed study is intended to inform the hypotheses that (1) regular dosing of exoskeleton walking will provide health benefits to non-ambulatory and poorly-ambulatory individuals with SCI, including decreased pain and spasticity, improvements in bowel and bladder function, decreased body-mass index (BMI), enhanced well-being; (2) regular dosing of exoskeleton walking will facilitate neurological or functional recovery in some individuals with SCI, particularly those with incomplete injuries; and (3) the level of mobility enabled by a lower limb exoskeleton is commensurate with the walking speeds, distances, and surfaces required for community ambulation.