A Study Using Spinal Stimulation During Exercise in Patients with Heart Failure


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-002521
    NCT ID: NCT02659202
    Sponsor Protocol Number: 14-002521

About this study

The purpose of this study is to determine if epidural spinal cord stimulation can affect blood pressure control and blood vessel resistance during exercise in heart failure patients by intercepting messages of muscle fatigue and shortness of breath.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Heart Failure patients with reduced ejection fraction
  • History of ischemic or idiopathic dilated cardiomyopathy (duration > 1yr) stable for > 3mo and New York Heart Association Class I-III
  • Not pacemaker dependent
  • Body Mass Index ≤35
  • Ejection Fraction < 40%
  • Current nonsmokers with < 15 pack year history
  • Able to exercise

Exclusion Criteria

  • History of cardiopulmonary disorders and dangerous arrhythmias
  • Pregnant women
  • Taking prescribed opioid medications or have had a fusion or laminectomy at L3 or above
  • Have a recent drug-eluding stent
  • History of spinal stenosis, lumbar radiculopathy, or peripheral neuropathy
  • Must not currently be taking blood thinners or anticoagulant medications

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Briana Ziegler



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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