A Study Using Spinal Stimulation During Exercise in Patients with Heart Failure


About this study

The purpose of this study is to determine if epidural spinal cord stimulation can affect blood pressure control and blood vessel resistance during exercise in heart failure patients by intercepting messages of muscle fatigue and shortness of breath.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Heart Failure patients with reduced ejection fraction
  • History of ischemic or idiopathic dilated cardiomyopathy (duration > 1yr) stable for > 3mo and New York Heart Association Class I-III
  • Not pacemaker dependent
  • Body Mass Index ≤35
  • Ejection Fraction < 40%
  • Current nonsmokers with < 15 pack year history
  • Able to exercise

Exclusion Criteria

  • History of cardiopulmonary disorders and dangerous arrhythmias
  • Pregnant women
  • Taking prescribed opioid medications or have had a fusion or laminectomy at L3 or above
  • Have a recent drug-eluding stent
  • History of spinal stenosis, lumbar radiculopathy, or peripheral neuropathy
  • Must not currently be taking blood thinners or anticoagulant medications

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Briana Ziegler



More information


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