EEG (electroencephalogram)

Displaying 27 studies

  • A Study to Map White Matter Cognitive Functions Using Stereo EEG Jacksonville, FL

    The purpose of this study is to examine the functional contributions of cerebral white matter (WM) tracts using stereo EEG electrical Stimulation mapping, to examine cognitive outcome in relation to the extent of mapped WM tract involvement in the surgical resection.

  • Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-827104 in Pediatric Subjects With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep Rochester, MN

    The primary objective of this study is to evaluate the long-term safety and tolerability of NBI-827104 in pediatric subjects with epileptic encephalopathy with continuous spike-and-wave during sleep (EECSWS) when administered for up to 106 weeks.

    Its secondary objectives are to investigate the effect of NBI-827104 on the overnight epileptiform video-electroeItephalogram (video-EEG) activity in pediatric subjects with EECSWS, and to investigate the long-term effect of NBI-827104 on the symptoms of EECSWS, including sleep and cognition, in pediatric subjects.

  • Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-827104 in Pediatric Subjects With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep Rochester, MN

    The purposes of this research are to assess the effect of NBI-827104, compared with placebo (no active drug), on the overnight epileptiform electroencephalogram (EEG) activity in pediatric participants with epileptic encephalopathy with continuous spike-and-wave during sleep (EECSWS), to evaluate the safety and tolerability of multiple doses of NBI-827104 in pediatric participants with EECSWS, and to evaluate the effect of NBI-827104 on sleep and on cognition in pediatric participants with EECSWS.

  • Study to Develop a Minimally-Invasive Seizure Gauge Rochester, MN

    The purpose of this study is to develop and validate all components of a minimally-invasive seizure detection and forecasting system.

  • EEG Cap for Identification of Non-Convulsive Status Epilepticus Jacksonville, FL

    Altered mental status (AMS) is one of the most common reasons for inpatient neurology consultation. Non-convulsive status epilepticus (NCSE) is frequently on the differential diagnosis of the patient with AMS. NCSE becomes more refractory to treatment after one hour of seizure activity, making rapid identification and treatment of NCSE of great clinical importance. Currently, an electroencephalogram (EEG) technologist must be called in from home during non-workday hours in order to obtain a stat EEG. The investigators propose the time required for diagnosis of NCSE at Mayo Clinic can be significantly decreased with rapid placement of an EEG cap by the ...

  • Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Monitoring of Patients with Epilepsy Rochester, MN

    The main purpose of the study is to demonstrate the performance and safety of the 24/7 EEG™ SubQ system as a reliable ultra long-term recorder of epileptic electrographic seizures. First, by comparison to simultaneously recorded video-EEG in the epilepsy monitoring unit (gold standard). Second, by comparison to self-reported seizure log books throughout 12-52 weeks of outpatient EEG monitoring.

  • Development of an EEG Diagnostic for Repetitive Sub-concussive Head Impacts Scottsdale/Phoenix, AZ

    The purpose of this study is to build on previous work, replicating the experimental protocol for subconcussive intervention with soccer headers, while adding EEG measurements and using modern machine learning (ML) techniques to create a highly accurate diagnostic algorithm.

  • EEG Study of Cortical Dynamics in Dystonia Rochester, MN

    The aim of this protocol is to design a measurement paradigm that reliably detects EEG oscillatory patterns during movement, relaxation, or imagination.  These techniques will be applied to normal controls and dystonic patients to define differences in the patterns between the two groups.

  • A Study Evaluating the Use of 48-hour Ambulatory EEG Monitoring in Early Onset Alzheimer’s Disease Jacksonville, FL

    The purpose of this study is to characterize and study the relationship of the clinical risk factors and predictors of seizures and epilepsy in patients with Early Onset Alzheimer's Disease (EOAD) using a 48-hour CAA-EEG.

  • Quantitative EEG Correlates of Suicidal Behaviors in Children and Adolescents Rochester, MN

    The purpose of this study is to examine qEEG correlates of suicidal ideations and behaviors (SIBS) (screened by the Columbia-Suicide Severity Rating Scale (C-SSRS)) in hospitalized adolescents between the ages of 13-18 years as compared to age-matched healthy participants.

  • A Study of Neurophysiological and Inflammatory Biomarkers of Seizures and Brain Injury in Children Rochester, MN

    The purpose of this study is to connect brain inflammation measured by biomarkers, with data from advanced EEG technology, and clinical outcomes to provide new predictive information about seizure activity in children with critical brain injuries and epilepsy.

  • A Study to Develop an EEG Diagnostic for Alzheimer’s Disease Scottsdale/Phoenix, AZ; Rochester, MN

    This study aims to obtain EEG data on individuals at all stages of AD from preclinical through severe dementia.

  • A Study to Detect Non-convulsive Seizures with Single-channel Electroencephalogram (EEG) Rochester, MN

    The purpose of this study is to assess how accurately a portable single-channel EEG device (Epilog™ by Epitel) detects generalized non-convulsive seizures, and to determine the feasibility of use of this device in an acute setting such as the Emergency Department (ED).

  • A Study of the Thalamus Using Deep Electrode EEG to Better Understand its Participation in the Beginning or Spreading of Seizures Rochester, MN

    The purpose of this study is to assess the thalamus area of the brain using stereotactic electroencephalography (an EEG with deep electrode placement inside the brain) to better understand its role in the starting and spreading of epileptic seizure activity.

  • Prevention of West Syndrome Rochester, MN

    The purpose of this study is to collect medical information from a group of infants in order to better understand West syndrome. EEG tests are usually ordered when infants have movements that look like seizures or infantile spasms. If there is hypsarhythmia, then the doctors know to give the specific treatment for West syndrome. We would like to see if there is EEG pattern that is always present even before the infantile spasms start and West syndrome diagnosed.

  • Development of a Practical, Minimally Invasive Seizure Gauge Rochester, MN

    The purpose of this study is to search for reproducible changes in a wide range of physiological signals, including photoplethysmography, accelerometry, heart rate, muscle tone and activity and EEG preceding and at the onset of seizures in patients with epilepsy.

  • A Study of a New Recording Electrode to Record Brain Activity During Surgery Rochester, MN

    This research study will investigate a new recording electrode that will record brain activity during surgery. This electrode is being tested for efficacy, and may eventually replace the current electrodes used for this purpose. The goal is to record brain activity in a region of the brain that is already being removed to treat epilepsy.

  • A Study to Gather a Database of Normal and Epilepsy Brain Scans Rochester, MN

    The purpose of this study is to build a database to do comparison studies of epilepsy patients and normal controls with Magnetic Resonance Imaging(MRI) and Electroencephalogram (EEG).

  • Is physical exercise associated with significant changes in the frequency or burden of spikes on EEG in children with epilepsy? Rochester, MN

    This study hypothesises that physical exercise in children with epilepsy will be associated with a significant reduction in interictal spikes and a significant reduction in spike burden.

    This study aims to determine if vigorous physical exercise results in significant increases or reductions in spike frequency in children on continuous video EEG monitoring.

  • A Study to Evaluate Brain Computer Interface (BCI) and Electrocorticography (ECoG)- based Mapping of Sensori-motor and Language Modalities Utilizing Subdural Electrodes in the Human Brain Jacksonville, FL

    The purpose of this study is to advance our understanding of the connectivity, causal role, and dynamic modulation of inter-areal communication in the human brain by recording electrocorticographic (ECoG) and stereoencephalographic (SEEG) brain signals during visual, auditory and sensory-motor tasks in patients awaiting invasive brain surgery with a particular focus on cortical networks engaged in perception of speech, language, and music.

  • Multiscale EEG Dynamics Rochester, MN

    The purpose if this study  to combine state of the art cerebral signal processing techniques and localization methods with intracranial electrode recordings to investigate the interaction of local hippocampal and neocortical networks with distributed brain activity.

  • A Study of Mood Symptoms in Epilepsy Patients Rochester, MN

    The purpose of this study is to track neuropsychiatric symptoms in patients with epilepsy.

  • Effect of Timing of Commencement of BIS Monitoring in Relation to Muscle Relaxant Administration Rochester, MN

    The primary objective of this study is to determine if the commencement of BIS monitoring relative to the administration of muscle relaxants has any effect on BIS values. The current study is a continuation of the project: “Bispectral Index: A Comparison of Bifrontal Montage Agreement” by Dr. Matthew Ritter and Wade Kreun, SRNA which validated the concurrent bifrontal use of BIS sensors. BIS monitors are FDA approved to assess the depth of sedation by analyzing segments of electroencephalogram (EEG) waves. They consist of a sensor, a digital signal converter, and a monitor. A BIS score is not a physiologic measurement, ...

  • Using Transcranial Magnetic Stimulation Evoked Potentials to Diagnose Rochester, MN

    The main objective of this study is to test whether individuals with schizophrenia spectrum disorders exhibit quantifiable abnormalities in transcranial magnetic stimulation (TMS) evoked electroencephalographic (EEG) potentials (TEPs); and whether social and non-social cognitive performance in patients with schizophrenia spectrum disorders are correlated with TEP abnormalities.

  • A Study to Compare Bifrontal Montage Agreement Rochester, MN

    The purpose of this study is to determine measurement difference and variability of bispectral index (BIS) values when monitored in a bilateral frontal montage.

  • A Study to Evaluate Biomarker Target Stimulation Rochester, MN

    The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.

  • A Study to Evaluate Feasibility of Microburst Vagus Nerve Stimulator (VNS) Therapy Jacksonville, FL

    The purpose of this study is to evaluate the initial safety and effectiveness of Microburst VNS stimulation in subjects with refractory epilepsy.


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