A Study to Evaluate Biomarker Target Stimulation


About this study

The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients 3 - 110 days old with drug resistant focal and generalized epilepsy and normal cognitive function undergoing intracranial EEG recording as part of their evaluation for epilepsy surgery.
  • Patients that are anticipated to undergo intracranial EEG electrodes will be prioritized for the study. This includes patients with stereoEEG electrodes, depth electrodes, and subdural neocortical strips or grids.

Exclusion Criteria:

  • Patients believed to be at increased risk of infection or hemorrhage.
  • Exclude if cognitive abilities of patient preclude performed required study tasks.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Gregory Worrell, M.D., Ph.D.

Open for enrollment

Contact information:

Karla Crockett

(507) 538-4880


More information


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