Is physical exercise associated with significant changes in the frequency or burden of spikes on EEG in children with epilepsy?


About this study

This study hypothesises that physical exercise in children with epilepsy will be associated with a significant reduction in interictal spikes and a significant reduction in spike burden.

This study aims to determine if vigorous physical exercise results in significant increases or reductions in spike frequency in children on continuous video EEG monitoring.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

  1. Child or teen aged 7-19 years, on continuous EEG monitoring with a history of probable seizures


Exclusion criteria:

1.         In pediatric intensive care unit

2.         Motor or developmental delay which would limit ability to exercise on a stationary bike

3.         Cardiac or other medical condition which could deteriorate with exercise

4.         Excessive sedation or ataxia, which would limit ability to exercise safely on a stationary bike

5.         Lack of consent and assent

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Elaine Wirrell, M.D.

Contact us for the latest status

Contact information:

Elaine Wirrell M.D.

More information


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