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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 11 for Pediatric brain tumors

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  • Study status: Open/Status Unknown
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  1. Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

    Rochester, MN

  2. Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients with Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorder

    Rochester, MN

  3. A Study to Evaluate the Feasibility of Memantine in Reducing Cognitive Impairment in Pediatric Patients After Radiation Therapy for Central Nervous System Tumors

    Rochester, MN

  4. Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

    Rochester, MN

  5. Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies

    Rochester, MN

  6. Cognitive Function After Treatment of Primary CNS Malignancy

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  7. A Study to Develop Liquid Biopsy for Pediatric Brain Tumor Patients

    Rochester, MN

  8. Neuropsychological and Behavioral Testing in Young Patients with Cancer

    Rochester, MN

  9. A Registry Called Every Child for Collecting Data and Biology Specimens on Younger Patients with Cancer

    Rochester, MN

  10. Developing Criteria for Treatment of Neurofibromatosis Type 1 Associated Optic Pathway Glioma

    Rochester, MN


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