A Study to Develop Liquid Biopsy for Pediatric Brain Tumor Patients
Tab Title Description
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Rochester, Minnesota: 19-004863
Sponsor Protocol Number: 19-004863
About this study
The purpose of this study is to confirm detection of the H3K27M mutation in patient biofluids (CSF, blood, urine, saliva) and uncover the molecular histone (alkaline protein) profile of H3K trimethylation and H3S phosphorylation in the circulating nucleosomes isolated from the biofluids of patients with H3K27M tumors.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
- Patients ≤ 21 years of age at time of consent.
- Clinical and radiographic evidence of a brain tumor.
- This includes gliomas, ependymomas, medulloblastomas or low grade glioma or gliosis. The pathology will be confirmed after the sample is obtained during the surgery.
- Tissue sample of the suspected lesion(s) is to be obtained by means of elective surgery as part of clinical management.
- Emergency surgery.
- Previous surgery or treatment history will not be an exclusion criteria.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
|Mayo Clinic Location
Mayo Clinic principal investigator
David Daniels, M.D., Ph.D.
Open for enrollment
Cancer Center Clinical Trials Referral Office
Publications are currently not available
Study Results Summary
Not yet available
Supplemental Study Information
Not yet available