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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 21-30 of 37 for Colon cancer

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  1. A Study to Evaluate Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy for HER2+ Gastrointestinal Cancers

    Scottsdale/Phoenix, AZ

  2. Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177)

    Scottsdale/Phoenix, AZ, Rochester, MN, Scottsdale/Phoenix, AZ, Rochester, MN

  3. A Study to Evaluate Exercise for Cancer Patients at Risk of Falling

    Rochester, MN

  4. A Study of Grapiprant and Pembrolizumab in Patients with Advanced or Progressive MSS Colorectal Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  5. A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  6. A Phase 1b/2 Study of Onvansertib (PCM-075) in Combination with FOLFIRI and Bevacizumab for Second-Line Treatment of Metastatic Colorectal Cancer in Patients with a KRAS Mutation

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  7. A Study of a Personalized Neoantigen Cancer Vaccine

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  8. A Study of Preventive Treatment of Oxaliplatin Induced Peripheral Neuropathy in Metastatic Colorectal Cancer (POLAR-M)

    La Crosse, WI

  9. An Investigational Immuno-therapy Study to Assess the Safety, Tolerability and Effectiveness of Anti-LAG-3 With and Without Anti-PD-1 in the Treatment of Solid Tumors

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

  10. A Study to Evaluate the Challenges, Behavioral Patterns, and Preferences of Minority Patient Participation in Clinical Trials

    Jacksonville, FL, Scottsdale/Phoenix, AZ, Rochester, MN

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