A Bio-bank for Patients with Inflammatory Bowel Disease Associated Neoplasia

Overview

About this study

The purpose of this study is to collect blood and stool samples to validate and improve the performance of stool and blood DNA markers for inflammatory bowel disease and colorectal neoplasia critical to the long-term goal of improving effectiveness of neoplasia detection in patients using non-invasive biomarkers to assist colonoscopy and radiographic screening. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • A diagnosis of ulcerative colitis or Crohn’s or indeterminate colitis with known dysplasia or cancer
  • A clinical evaluation with a colonoscopy or surgery scheduled within 120 days of sample collection
  • Has had a clinical evaluation colonoscopy within the last 120 days before sample collection

Exclusion Criteria 

  • Younger than 18 years of age
  • Has undergone a biopsy of the target neoplastic pathology in the last 7 days (relative contraindication)
  • Has undergone a therapeutic intervention to treat or remove the target pathology
  • Has received chemotherapy class drugs or therapeutic radiation in the last 5 years
  • Has a primary cancer diagnosis anywhere in the body in the last 5 years (non-including non-melanoma skin cancer) (ineligible for blood collection)
  • Has cancer of the mouth, esophagus, lung or GI tract (ineligible for stool collection)
  • Has Barrett’s esophagus (ineligible for stool collection)
  • Has ileostomy (ineligible for stool collection)
  • Is currently on a non-oral diet (using G or J tube or TPN) (ineligible for stool collection)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Kisiel, M.D.

Open for enrollment

Contact information:

Kari Lowrie

(507)266-3778

Lowrie.Kari@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available