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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 87 for spine

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  1. Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery

    Rochester, MN

  2. A Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries

    Rochester, MN

  3. A Study of Lofexidine for Rapid Opioid Tapering in Adults

    Rochester, MN

  4. A Mobile Application for Next Generation Patient Evaluation, Follow-Up, and Outcomes Monitoring

    Rochester, MN

  5. Evaluating Adult Patient Temperatures During Lower Spinal Surgery

    Rochester, MN

  6. A Study to Evaluate Post-surgical Outcomes Using the Early Recovery After Surgery (ERAS) Protocol for Posterior Cervical Decompression and Fusion

    Scottsdale/Phoenix, AZ

  7. A Study of the Effectiveness of EXPAREL for Pain Control in Adult Subjects Undergoing Open Lumbar Spinal Fusion Surgery

    Rochester, MN

  8. A Study Comparing Effectiveness and Safety of SPIRA-A Anterior Lumbar Interbody Fusion Device to PEEK Anterior Lumbar Interbody Fusion Cage with rhBMP-2 in Instrumented Lumbar Fusions

    Rochester, MN

  9. A Study of Bowel Function Return After One or Two Level Anterior Lumbar Interbody Fusion with Chewing Gum

    Scottsdale/Phoenix, AZ

  10. Study of Lumbar Discectomy with Additional Implantation of an Annular Closure Device in Patients with Large Postsurgical Annular Defects

    Jacksonville, FL

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