A Study of Comparing Functional Outcomes after Kinematic and Mechanical Alignment in Total Knee Arthroplasty

Overview

About this study

The study aim is to conduct a clinical research investigation to compare two alignment techniques used in contemporary total knee arthroplasty by means of a prospective non-randomized clinical trial. The two alignment techniques are Kinematic Alignment (KA) and Mechanical Alignment (MA).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

  • Primary arthroplasty
  • Age between 45 and 80 years old
  • Single condylar implant design

Exclusion Criteria:

  • Revision arthroplasty
  • Age less than 45 and greater than 75 years old
  • Pre-operative flexion lower than 90 degrees
  • Valgus or varus knee deformity greater than 15 degrees
  • The presence of infections, highly communicable diseases (AIDS, active tuberculosis, venereal disease, hepatitis) or metastasis disease
  • Significant neurological or musculoskeletal disorders or disease that may interfere with normal gait or weight bearing
  • Any congenital, developmental, or other bone disease or previous hip surgery that may, in the surgeon’s judgment, interfere with TK prosthesis survival or success
  • Presence of previous prosthetic knee or hip replacement device
  • BMI > 30
  • Pregnant women

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Mark Pagnano, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20314172

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