A Study Comparing Management of Postoperative Pain after Total Knee Replacement


About this study

The purpose of this study is to compare two methods of postoperative pain management for patients who have undergone total knee replacement surgery.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Unilateral primary total knee replacement
  • Weight of 50-125 kg
  • Age 18-79 years
  • Intact neurological exam to the surgical lower extremity
  • Cognitively intact with ability to sign informed consent

Exclusion Criteria

  • Renal insufficiency with creatinine >1.5 mg/dL
  • Allergy to the medication used in the study
  • Using narcotic medication prior to surgery (morphine equivalents ≥ 20 mg/day for > 7 days)
  • Prior open knee surgery with regional anesthesia or periarticular injection for post-operative pain management

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Mark Spangehl, M.D.

Closed for enrollment

More information


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