A Study to Evaluate Manipulation Under Anesthesia After Bilateral Primary Total Knee Arthroplasty


About this study

The purpose of this study is to determine unique genetic profile of patients requiring MUA following bilateral pTKA via genetic sequencing, to determine outcomes of patients receiving MUA in terms of KSS, implant durability, survival free of reoperation, and to define characteristics and comorbidities of patients undergoing unilateral and bilateral MUA.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age > 18 years old.
  • Primary total knee performed, 2000-2019.
  • Development of knee stiffness requiring manipulation under anesthesia.
  • Primary surgery and manipulation performed at Mayo Clinic Rochester, MN.

Exclusion Criteria: 

  • Age < 18 years old.
  • Pregnant women.



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Matthew Abdel, M.D.

Open for enrollment

Contact information:

Lauren Cole B.S.

(507) 266-1227


More information


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