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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 191-200 of 846 for cardiovascular

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  1. Safety and Efficacy of ANX-042 in Human Cardiorenal Syndrome

    Rochester, MN

  2. The Effects of Acute and Chronic Exercise on the Immune Phenotype in Healthy Patients

    Rochester, MN

  3. Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI)

  4. Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement

    Rochester, MN

  5. The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosis

    Jacksonville, FL, Rochester, MN

  6. Grit as a Predictor of Outcomes in Transcatheter Valvular Therapeutic Candidates

  7. Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure

    La Crosse, WI, Jacksonville, FL

  8. A Study to Evaluate Electrocardiogram Artificial Intelligence-Guided Screening for Low Ejection Fraction (EAGLE)

    Rochester, MN

  9. A Study to Evaluate the Effectiveness of The Portable Organ Care System (OCS™) Heart from Donors After Circulatory Death Heart

    Jacksonville, FL

  10. Cardiothoracic Resident and Fellow Operative Autonomy (Zwisch Me!)

    Rochester, MN

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