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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 171-180 of 845 for cardiovascular

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  1. Fluid Volume During Fluid Shifts

    Rochester, MN

  2. A Study to Evaluate the Long-Term Safety and Effectiveness of Ubenimex in Patients with Pulmonary Arterial Hypertension

    Rochester, MN

  3. Studies on the Health Benefits of Pulsed Electromagnetic Field Therapy using Bioboosti

    Scottsdale/Phoenix, AZ

  4. A Study to Determine the Effects of Cardiac Resynchronization Therapy on Blood Vessel Tissue and Heart Function for Patients with Heart Failure

    Rochester, MN

  5. A Study of the FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT Study

    Rochester, MN

  6. A Study of the Long-Term Safety of Tafamidis in Subjects with Transthyretin Cardiomyopathy

    Scottsdale/Phoenix, AZ

  7. Study and Safety Monitoring of Patients with Symptomatic Transthyretin Cardiomyopathy Who Have Completed the Phase II Study AG10-201

    Rochester, MN

  8. Review of the Safety and Effectiveness of the THERMOCOOL SMARTTOUCH® SF Catheter Evaluated for Treating Symptomatic PersistenT AF (PRECEPT)

  9. A Study to Compare FEIBA to Alternative Blood Products in Treating Children After Cardiac Surgery

    Rochester, MN

  10. A Study to Compare Post-exercise Treadmill versus Supine Bicycle Exercise Left Ventricular Outflow Tract Gradients Assessed by Echocardiography in Hypertrophic Cardiomyopathy

    Rochester, MN

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