A Study of Mechanisms of Altered Ventilatory Control in Heart Failure

Overview

  • Study type

    Interventional
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 12-005318
    NCT ID: NCT02421341
    Sponsor Protocol Number: 12-005318

About this study

This study is being done because the investigators are trying to understand how feedback from the muscles can influence your blood pressure and breathing during exercise, and if the investigators can reduce this response in heart failure patients. The investigators are also trying to determine ways to improve tolerance to exercise in heart failure patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria Heart Failure Patients:

  • History of Heart Failure with preserved ejection fraction or with reduced ejection fraction
  • No history of dangerous arrhythmias
  • Body Mass Index less than or equal to 35 kg/m
  • Current non-smokers with less than 15 pack year history
  • Non-pregnant women
  • Individuals who are able to exercise without orthopedic limitations
  • All patients will be managed by their primary care physician or cardiologist prior to enrollment to ensure inclusion and exclusion criteria have been satisfied and participation in exercise testing is safe.

Inclusion Criteria Control Participants:

  • Will be matched for age, gender, height and weight and will have no history of cardiovascular related abnormalities.
  • Body Mass Index less than 35 kg/m
  • Current non-smokers with less than 15 pack year history
  • Non-pregnant women
  • Individuals who are able to exercise without orthopedic limitations

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Thomas Olson, Ph.D., M.S.

Open for enrollment

Contact information:

Briana Ziegler

(507)255-7125

Ziegler.Briana@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20209370

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