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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 287 for Digestive Diseases

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  • Study status: Open/Status Unknown
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  1. Sponge and Eosinophil Peroxidase (EPO) Staining

    Rochester, MN

  2. Trial of Specific Carbohydrate and Mediterranean Diets to Induce Remission of Crohn's Disease

    Rochester, MN

  3. Phase II Study of EUS-guided Verteporfin PDT in Solid Pancreatic Tumors

    Rochester, MN

  4. A Study to Evaluate the Safety and Immunological Effect of Pembrolizumab in Resectable or Borderline Resectable Pancreatic Cancer

    Scottsdale/Phoenix, AZ

  5. Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients with Locally Advanced Rectal Cancer Undergoing Surgery

    Scottsdale/Phoenix, AZ, Rochester, MN, Scottsdale/Phoenix, AZ, Rochester, MN

  6. Study to Explore the Therapeutic Effect of Eluxadoline in Treating Irritable Bowel Syndrome With Diarrhea in Children

    Rochester, MN

  7. A Study to Assess the Safety and Tolerability of Single and Multiple Doses of KAN-101 in Celiac Disease Patients

    Rochester, MN

  8. Adipose Derived Stromal Vascular Fraction for Aero-digestive & Enterocutaneous Fistulae

    Jacksonville, FL

  9. Transforming Non-Invasive Liver Disease Detection by Magnetic Resonance Elastography

    Rochester, MN

  10. Mayo Clinic Health TAPESTRY: Use of Genomic Sequencing in Clinical Practice

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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