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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 41-50 of 266 for Digestive Diseases

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  • Study status: Open/Status Unknown
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  1. A Study to Evaluate Dynamic Positron Emission Tomography Imaging to Explain Macrophage Activation in Diabetic Gastroparesis

    Rochester, MN

  2. Stem Cell Coated Fistula Plug in Patients With Crohn's RVF

    Rochester, MN, Rochester, MN

  3. A Study to Evaluate the Safety, Tolerability, and Activity of Escalating Doses of AK002 in Patients with Eosinophilic Gastritis (EG) and/or Eosinophilic Gastroenteritis (EGE)

    Rochester, MN

  4. MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients

    Rochester, MN

  5. A Study to Understand the Mechanisms of Normal and Disordered Defection

    Rochester, MN

  6. A Study of Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients with Pancreatic Cancer with Vascular Involvement

    Rochester, MN, Jacksonville, FL

  7. A Study of Sonidegib and Pembrolizumab in Advanced Solid Tumors

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  8. A Study of Oral Ozanimod as Maintenance Therapy for Moderately-to-Severely Active Crohn's Disease

    La Crosse, WI

  9. A Phase I, Multi-Center, Open Label, Dose De-escalation and Expansion Study of Gemcitabine and Cisplatin with AG120 or Pemigatinib for Advanced Cholangiocarcinoma

    Rochester, MN, Scottsdale/Phoenix, AZ

  10. A Study Evaluating the Safety and Effectiveness of BIV201 and Standard of Care Compared to Standard of Care to Reduce the Recurrence of Ascites and Complications in Patients with Refractory Ascites Secondary to Decompensated Liver Cirrhosis

    Jacksonville, FL, Rochester, MN

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