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  • Dexamethasone Suppression Test in Healthy Volunteers Rochester, Minn.

    The purpose of this study is to establish a reference range for free cortisol following dexamethasone administration in 100 volunteers without suspicion of cortisol excess.

  • Phase 2 Study of the Safety and Efficacy of CORT125134 in the Treatment of Endogenous Cushing's Syndrome Rochester, Minn.

    Cushing's syndrome is a relatively rare disorder caused by prolonged exposure to high levels of the glucocorticoid hormone cortisol. Cushing's syndrome may result from elevated endogenous or exogenous sources of cortisol. Endogenous Cushing's syndrome resulting from cortisol overproduction by the adrenal glands is the subject of this protocol. Patients with exogenous Cushing's syndrome, which develops as a side effect of chronic administration of high doses of glucocorticoids, are not eligible for enrollment in this study. The purpose of this study is to evaluate the safety and efficacy of CORT125134 for treatment of endogenous Cushing's syndrome. The multicenter study will be conducted in the United States and in Europe.

  • Prospective, Non-interventional Clinical Study of Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery Rochester, Minn.

    This study will investigate the potential for FK506 binding protein 5 (FKBP5) (and other gene expression markers, for example pentraxin 3 [PTX-3], serum/glucocorticoid regulated kinase 1 [SGK1], and glycogen synthase kinase 3 beta [GSK3b]) to be developed as a biomarker for use in diagnosis of Cushing's syndrome, assessment of effectiveness of medical or surgical treatment, and detection of relapse of endogenous Cushing's syndrome after surgery.

  • The Effect of Exogenous Estrogen Therapy on Total and Free Serum Cortisol Levels in Healthy Women Rochester, Minn.

    The purpose of this study is to determine the effect of estrogen-based contraceptive therapy on baseline and peak total and free cortisol levels in healthy women undergoing the Cosyntropin stimulation test.