Clinical Trials

Inclusion criteria:

• Adults, 18 years or older, with PAI or adults without PAI (referent population)
• Stable glucocorticoid and mineralocorticoid regimen in the last 6 weeks and no plans to change the regimen within the 4 weeks post-visit (outside from stress dosing)
• Patient provided smartphone and ability to access and use internet/email.
• iOS devices running Apple iOS 15 and higher, or Android devices running Android 9 and higher. Device must support Bluetooth 4.0
• Willing to wear Oura ring for a minimum of 6 months and maximum of duration of the study/duration of ring function, particularly at night/while sleeping. Open Oura app daily (data syncing).
• Willing to participate in baseline procedures.
• Willing to complete redcap collection form to document symptoms, glucocorticoid dose changes, and medical events.
• Willing to complete longitudinal redcap forms on quality of life, sleep, and cognition.

Exclusion criteria:

• Glucocorticoid injection within the last 6 weeks from baseline assessment.
• Glucocorticoid other than hydrocortisone and prednisone.
• Pregnancy at baseline visit.
• PI decision of ineligibility due to medication/comorbidity/other.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 3/27/2025. Questions regarding updates should be directed to the study team contact.