Bone Health in Patients with/without Adrenal Disease


About this study

The purpose of this study is to determine prevalence and incidence of osteopenia, osteoporosis, and fractures in patients with adenomas based on hormonal sub-type, and to determine the effect of abnormal steroid metabolome on bone density, bone metabolism, and fractures.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult ≥ 18 years old.
  • Diagnosis of either of the following conditions:
    • adrenal adenoma;
    • macro- or micronodular hyperplasia with available or planned dexamethasone suppression test result;
    • ACTH-dependent Cushing syndrome;
    • No adrenal disorder (as referent subject).
  • Ability to provide consent.

Exclusion Criteria: 

  • Individual < 18 years of age.
  • Inability to provide consent.
  • Exogenous Cushing syndrome,

Eligibility last updated 3/10/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Irina Bancos, M.D.

Open for enrollment

Contact information:

Vanessa Fell

(507) 266-6068

More information


Publications are currently not available

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