A Study of the Characteristics of Adrenal Steroid Production and Metabolism in Patients with Adrenal Tumors, Using Comprehensive Steroid Profiling


About this study

The purpose of this study is to characterize adrenal steroid synthesis and metabolism in patients with nonfunctioning adrenal tumors (NF), adrenal tumors with subclinical Cushing Syndrome (SCS) and Cushing Syndrome (CS). The study also aims to characterize altered metabolites and disruptive metabolic pathways, and to connect adrenalectomy-induced changes in β-cell function and insulin sensitivity with the preoperative metabolic profile in patients who have NF, SCS and CS adrenal tumors.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18 years old and above
  • Has adrenocortical adrenal mass with planned adrenalectomy
  • Adrenal imaging and hormonal work up is available

Exclusion Criteria:

  • Acute sickness
  • Active exogenous oral glucocorticoid therapy before surgery
  • Pheochromocytoma, adrenocortical carcinoma, adrenal metastasis or other suspected non-cortical adrenal mass, primary hyperaldosteronism
  • Pregnancy (due to the fact that steroid profile is affected by the pregnancy itself. However, testing for pregnancy will not be required in potential subjects as OGTT is a standard procedure during pregnancy not contributing to fetal risk)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Irina Bancos, M.D.

Open for enrollment

Contact information:

Melinda Thomas B.S.


More information


Publications are currently not available

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