Matthew P. Abdel, M.D.

The purpose of this study is to evaluate changes in pubic symphysis to sacrococcygeal junction distance (PSCD) between supine and standing anteroposterior (AP) pelvis radiographs and evaluate relationship between pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL), and PSCD.

This study is being conducted to determine gene and protein expression profiles (i.e. which genes and proteins are turned off and on) of those with a possibility of developing osteolysis, infection, arthrofibrosis or metallosis of their THA/TKA.

Some have suggested that targeting neutral alignment of the knee may improve outcomes after primary total knee arthroplasty (TKA). However, most of the discussion has focused on coronal alignment, with little emphasis on sagittal alignment, particularly tibial slope. The goals of this study were to determine the effect of tibial slope on implant survivorship and clinical outcomes of contemporary posterior-stabilized (PS) TKAs.

The purpose of this study is to determine unique genetic profile of patients requiring MUA following bilateral pTKA via genetic sequencing, to determine outcomes of patients receiving MUA in terms of KSS, implant durability, survival free of reoperation, and to define characteristics and comorbidities of patients undergoing unilateral and bilateral MUA.

The purpose of this study is to evaluate two different standards of care to see if the single Double Debridement, Antibiotics and Implant Retention (DAIR) protocol is non-inferior to planned double-DAIR protocols for acute Periprosthetic Joint Infection (PJI) after primary total hip arthroplasty (THA) or  total knee arthroplasty (TKA). Additionally, effectiveness of treatment in terms of infection eradication and cost comparisons will be addressed.

The objectives of this study are to evaluate changes in pubic symphysis to sacrococcygeal junction distance (PSCD), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL) between three separate evaluations in preoperative candidates for Total Hip Arthroplasty (THA), and to evaluate changes in pubic symphysis to sacrococcygeal junction distance (PSCD), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL) between three separate evaluations in postoperative THA patients.

The purpose of this retrospective cohort study is to evaluate module junction failure of the Zimmer revision systems including NexGen and Persona revision systems. 

The objectives are to report on the failure rate of Zimmer revision systems including NexGen and Persona revision systems at the modular junction site on femoral and tibial components, and to evaluate the risk factors and commonalities of patients who underwent revision total knee arthroplasty with Zimmer revision systems including NexGen and Persona revision systems and sustained failure at the modular junction site.

We will initially query Mayo Total Joints Registry database to obtain a list of patients who revision total knee arthroplasty with Zimmer revision systems including NexGen and Persona revision systems.  We will then search within this list for patients with a history of re-revision (unless revision components used in primary) or implant failure at modular junction site of femoral or tibial component. Cases will be reviewed up through 12/31/2019 to allow for two-year follow-up. We will review imaging of patients who meet this criterion including pre-operative/post-operative revision total knee arthroplasty radiographs, and Zimmer revision systems’ failure/injury radiographs. We will review these cases to find etiology of failure, specifically studying if this failure took place at the modular junction sites, and if so, at what rate. We will then complete a more detailed chart review of the included patients to help establish trends and commonalities between patients in this population whose hardware underwent failure. Once the data has been collected using chart and database review, we will complete statistical analyses help establish failure rate. We will also complete subgroup analysis to compare outcomes and risk factors of patients in this selected group. We will also contact patients in study view email and phone to further evaluate risk factors and outcomes.

This study has no financial implications or budget associated with implementation or data analysis.

The purpose of this study is to evaluate two different standards of care to see if the single Double Debridement, Antibiotics and Implant Retention (DAIR) protocol is non-inferior to planned double-DAIR protocols for acute Periprosthetic Joint Infection (PJI) after primary total hip arthroplasty (THA) or  total knee arthroplasty (TKA). Additionally, effectiveness of treatment in terms of infection eradication and cost comparisons will be addressed.

This study aims to assess pre- and postoperative serum mast cell tryptase levels in primary TKA patients to determine whether there is an association with the development of post-operative stiffness.

We will collect both non-invasive hemoglobin and conventional serum hemoglobin labs from patients postoperatively following outpatient total joint arthroplasty to determine how closely the values of these two studies correlate in the outpatient total joint arthroplasty patient population.

The purpose of this study is to perform independent analysis of optimal synovial fluid diagnostic cutoffs for acute periprosthetic joint infection of the knee.

The purpose of this study is to evaluate time to return of lower extremity motor function following mepivacaine versys low-dose bupivacaine spinal anesthetic among patients undergoing primary total hip arthorplasty (THA) and total knee arthroplasty (TKA).

The purpose of this study is to compare the outcome following manipulation under anesthesia for stiffness with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Measured outcomes will include pain, range of motion, as well as subjective outcome scores.

The purpose of this study is to investigate if bupivacaine +meloxicam ER solution is going to improve patient care at Mayo Clinic through superior and prolonged analgesia following total knee arthroplasty compared to our standard of care.

The purpose of this study is to determine whether topical or intravenous administration of tranexamic acid during unilateral total knee replacement is more effective at reducing bleeding in the first 24 hours following surgery. Tranexamic acid is a synthetic drug that has been shown to reduce blood drain output and the need for blood transfusions in both its topical and intravenous forms and is commonly used in orthopedic surgery. We hypothesize that IV and topical administration of tranexamic acid will be equally good at reducing the loss of blood and the need for transfusion immediately following total knee replacement.

Revision TKA for instability is fairly common occurring in up to 22% of revision procedures. Previous reports of revision TKA for flexion instability are limited in the length of follow-up as well as the number of patients. There is a paucity of studies with large series of total knee arthroplasty patients revised for flexion instability with midterm and long-term follow-up. The purpose of this study is to present the Mayo Clinic series of revision TKA patients with flexion instability and present the clinical outcomes including survivorship, complications, reoperations as well as patient reported and radiographic outcomes at mid- to long-term follow-up. 

The purpose of this study is to determine if modular dual mobility (MDM) hips are at risk of increased serum metal ion levels.

The purpose of this study is to evaluate the clinical outcomes, survivorship, and complications of HIV-positive patients undergoing total hip or total knee arthroplasty at the Mayo Clinic in the past 20 years.

To determine the optimal dosing regimen and route of administration of tranexamic acid (TXA) [single dose intravenous (IV), double dose intravenous, intravenous + topical, and oral repeated dosing] to minimize post-operative blood loss and transfusion requirements following revision total knee arthroplasty (RTKA).

The purpose of this study is to determine the best dosing plan and route of administration of tranexamic acid to minimize post-operative blood loss and transfusion requirements after a redo of a total knee replacement surgery.