A Study to Assess Diagnostic Thresholds for Acute Periprosthetic Infection


About this study

The purpose of this study is to perform independent analysis of optimal synovial fluid diagnostic cutoffs for acute periprosthetic joint infection of the knee.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with a reoperation within 12 weeks following a primary total knee arthroscopy (TKA).

Exclusion Criteria:

Patients who/with:

  • Were missing synovial fluid analysis data.
  • Did not have culture data.
  • Previous revision surgery on the same knee.
  • Sameday (postoperative day (POD) 0) re-operation.
  • Superficial (extraarticular) irrigation and debridement.
  • Diagnosis of acquired immunodeficiency syndrome (AIDS) or malignancy.
  • Received antibiotics within 2 weeks of synovial fluid aspiration.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Matthew Abdel, M.D.

Closed for enrollment

More information


Publications are currently not available

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