Clinical Trials

The purpose of this study is to assess differences in acoustic, prosodic, and temporal voice features between patients with and without gastroesophageal reflux (GER) symptoms. To achieve this aim, we will study the differences in voice between patients with and without GER symptoms. Evaluate differences in acoustic, prosodic, and temporal voice features between individuals with GER before and after treatment with proton pump inhibitor (PPI) therapy. To achieve this, we will compare patients’ voice features at baseline and both 4- and 8-weeks after the initiation of acid suppression therapy. At minimum, patients will be instructed to take a ...

In patients with gastroesophageal reflux and/or laryngopharyngeal reflux with cricopharyngeal hypertrophy or Zenker's diverticulum, does cricopharyngeal myotomy increase the amount of laryngopharyngeal reflux?

The aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of GERD and visceral acid hypersensitivity.

The purpose of this study is to determine if an artificial intelligence (AI) program can efficiently determine whether patients have gastro-esophageal reflux disease (GERD) via voice recordings and AI training.

The purpose of this study is to evaluate and compare esophageal high resolution impedance manometry (HRIM)  with direct mucosal impedance  catheter diagnostic measurements in patients with gastroesophageal reflux disorder.

This study aims to understand why patients have predominantly upright gastroesophageal reflux disease by comparing such patients to healthy persons AND whether a behavioral intervention (diaphragmatic breathing) will impact this disease

The purpose of this study is to gather information and determine if one achalasia procedure at Mayo Clinic Rochester is superior to the other.  

The purpose of this study is to identify a predictive model for worsening of preexisting gastroesophageal reflux disease (GERD) or development of de novo GERD after laparoscopic sleeve gastrectomy (LSG) by using EndoFLIP, upper endoscopy and esophageal manometry to assess patients preoperatively in a discovery cohort.  This prospective predictive model will then identify sensitivity, specificity, positive and negative predictive values for prediction of worsening or de novo GERD.

This registry is intended as an observational, post-marketing surveillance tool. The purpose of this registry is to collect baseline demographics and user experience of the commercially available MUSE (Medigus Ultrasonic Endostapler) system for the treatment of gastroesophageal reflux disease. The data collection aims to gather a minimum of 3 years follow-up on a large number of subjects during use of the system outside of a prescribed clinical study.

The purpose of this study is to establish if abdominal breathing exercises can reduce symptoms associated with reflux.

The purpose of this study is to demonstrate the safety and effiectiveness of Aluvra for the treatment of GERD.

The purpose of this study is to evaluate the accuracy of balloon catheter based mucosal impedance for the diagnosis of GERD in patients who have undergone Peroral Endoscopic Myotomy (POEM).

This study is being done to determine if people with and without GERD or trouble swallowing have increased esophageal mucosa impedance (food getting into the esophageal tissue).

This is a mechanistic research study to evaluate the relationship between cough, reflux, and aspiration in patients with systemic sclerosis (scleroderma).

Is waist to hip ratio (WHR), waist circumference (WC), (as markers of visceral adiposity) associated with an increase in acidic and non acidic reflux as well as systemic inflammation involving esophageal mucosa, thereby increasing esophageal injury and predisposing to subsequent development of Barrett's esophagus (BE)?

The purpose of this study is to compare treatment effectiveness and safety between Transoral Incisionless Fundoplication (TIF) and Laparoscopic Nissen Fundoplication (LNF) in GERD patients with hiatal hernia undergoing hernia repair.

The purpose of this study is to learn more about the prevalence of gastroesophageal reflux among patients with esophagitis using long term proton-pump-inhibitor use.

The investigators would like to determine if there are patients with PPI responsive Eosinophilic Esophagitis Infiltration that have significant loss of esophageal distensibility suggestive of esophageal fibrosis typical of classic Eosniophilic Esophagitis.

If this group of patients exists, the investigators would like to determine if they have the typical endoscopic features of EoE rather than those of GERD.

Prospective registry comparing outcomes after laparoscopic treatment of gastroesophageal reflux disease and hiatal hernia.

This study will use a 22 gene pharmacogenomics panel on 30 children with persistent Gastroesophageal Reflux Disease (GERD) who have not responded to therapy.

This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

The purpose of this study is to Measure and compare BE screening rates with and without a multicomponent intervention, in a pragmatic cluster randomized trial.

The purpose of this study is to collect data related to patients undergoing diagnostic evaluation and treatment of Gastroesophageal Reflux Disease (GERD) and its associated diseases in multiple academic and community settings.