A Study of High Resolution Impedance Manometry versus Direct Mucosal Impedance Catheter for Diagnostic Measurements in Patients with Gastroesophageal Reflux Disorder


About this study

The purpose of this study is to evaluate and compare esophageal high resolution impedance manometry (HRIM)  with direct mucosal impedance  catheter diagnostic measurements in patients with gastroesophageal reflux disorder.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria

  • Adults ages 18-90
  • Patients scheduled for or have completed an HRIM ( within 5 days)
  • Patients scheduled for or recently have completed MII-pH studies ( within 5 days)
  • Patients scheduled for EGD

Exclusion Criteria

  • Technically limited esophageal HRIM or MII-pH study
  • Patients with HRIM and MII-pH studies not performed within 5 days of each other
  • Patients with EGD not performed within 30 days of HRIM and MII-pH studies
  • Medical conditions such as severe heart or lung disease that preclude safe performance of endoscopy
  • Inability to read due to
    • Blindness
    • Cognitive dysfunction
    • English language illiteracy

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Karthik Ravi, M.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


Mayo Clinic Footer